![]() Disrupting macrophage-Treg interactions with targeted drugs unleashes the efficacy of ICB, achieving regression of most tumors.Ĭianciaruso, C.*, Beltraminelli, T.*, Duval, F.*, Nassiri, S., Hamelin, R., Mozes, A., Gallart-Ayala, H., Ceada Torres, G., Torchia, B., Ries, C.H., Ivanisevic, J., & De Palma, M. Using genetically engineered mouse models of lung cancer, we identify a therapy-induced cross talk between macrophages and regulatory T cells (Tregs) that sustains tumor resistance to ICB. Key findings: Most lung cancers are resistant to immune checkpoint blockade (ICB) with PD-1 or PD-L1 antibodies, also in combination with front-line drugs. Overcoming microenvironmental resistance to PD-1 blockade in genetically engineered lung cancer models. Martinez-Usatorre, A.*, Kadioglu, E.*, Boivin, G., Cianciaruso, C., Guichard, A., Torchia, B., Zangger, N., Nassiri, S., Keklikoglou, I., Schmittnaegel., M., Ries, C.H., Meylan, E., & De Palma, M. The project will develop a new generation of cancer vaccines based on engineered dendritic cells. Miki has been awarded an ERC consolidator grant (CoG). Want to know more of how the tumor microenvironment regulates angiogenesis?ġ2/2016. Congratulations to Mario on the acceptance of his paper in Nature Methods!Ġ8/2017. Congratulations to Ioanna and Martina on the acceptance of their papers in Cell Reports and Science Translational Medicine!ġ1/2017. Miki is the 2017 recipient of the Robert Wenner Prize (for Italian click here) for cancer research, awarded by the Swiss Cancer League.ġ1/2017. Our work has been featured in Gen SuisseĠ2/2018. The review article “ Consensus guidelines for the use and interpretation of angiogenesis assays” is now published in Angiogenesis Journal.Ġ5/2018. Our review article on perivascular macrophages has been published in Nature Reviews Immunology. Congratulations to Ioanna and Chiara on the acceptance of their paper in Nature Cell Biology!Ġ8/2018. Congratulations to Chiara, Tim and Florent on the acceptance of their paper in Cell Reports!ġ1/2018. ![]() ![]() Congratulations to Mario on being awarded the Best Publication Award 2019 by the Associazione Giovanna Tosi for his recent paper on engineered dendritic cells. Our Review on engineered dendritic cell vaccines for cancer immunotherapy is available online in Nature Communications.Ġ6/201 9. Congratulations (again!) to Martina on the acceptance of her paper in PNAS, a study in collaboration with the Zippelius lab in Basel.ġ1/201 9. ![]() Initial r esults of our collaboration with Tanya Petrova‘s group just published in the Journal of Clinical Investigation: Anti-angiogenic immunotherapy for chemoresistant colorectal cancer.Ġ1/2020. Perhaps interested in the phylogeny and taxonomy of Goliathus beetles?Ġ2/2020. Our new Review on tumour-associated macrophages is published in the Journal of Pathology.Ġ2/2020. Our new Review on extracellular vesicles in cancer is published in Cell Reports.Ġ2/2020. Congratulations to Amaia and Ece on the publication of their study on immunotherapy resistance in lung cancer, which is out now in Science Translational Medicine.Ġ4/2021. Furthermore, we examine how the interplay between the tumor and the host can be harnessed for improving tumor response to anti-cancer therapies, in particular immunotherapies.Ġ8/2021. This is being studied primarily in genetic models of breast and lung cancer, and melanoma, in which both malignant and host cells are engineered to be visualized or depleted, or to modify their expression of genes of interest. We focus on the cross talk between malignant cells and the vascular system, immune cells, and secreted extracellular vesicles (exosomes), and the mechanisms whereby these heterotypic interactions regulate tumor progression in experimental cancer models. Our laboratory investigates the interactions between genetically altered cancer cells and the ostensibly normal host tissues in which tumors arise, progress and develop to metastatic disease. ![]()
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